Vascular actions of MDMA involve α1 and α2‐adrenoceptors in the anaesthetized rat

Abstract

We have investigated the effects of methylenedioxymethamphetamine (MDMA,'ecstasy'), iv, on diastolic blood pressure (DBP) in pithed and pentobarbitone anaesthetized rats. In pithed rats, the non‐selective 5‐HT receptor antagonist methiothepin (0.1 mg kg− 1) and the α2 …