The molecular mechanism of" ecstasy": serotonin transporters are targets for MDMA-induced serotonin release.

Abstract

MDMA (" ecstasy") has been widely reported as a drug of abuse and as a neurotoxin. This report describes the mechanism of MDMA action at serotonin transporters from plasma membranes and secretory vesicles. MDMA stimulates serotonin efflux from both types of …