Sprague–Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3, 4-methylenedioxymethamphetamine (MDMA, ecstasy)

Abstract

The use of the amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) has been associated with unexplained deaths. Male humans and rodents are more sensitive to acute toxicity than are females, including a potentially lethal hyperthermia …