Role of brain nitric oxide in (±) 3, 4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats

Abstract

The role of nitric oxide (NO) in the long-term serotoninergic neurotoxicity induced by (±) 3, 4-methylenedioxymethamphetamine (MDMA) in rats was investigiated. Pretreatment with N ω-nitro-l-arginine (l-NOARG)(10 mg kg− 1), a nitric oxide synthase (NOS) inhibitor, partially …