Persistent MDMA‐induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice

N Granado, E O'Shea, J Bove, M Vila… - Journal of …, 2008 - Wiley Online Library

Author(s): Maria Esther O´Shea Gaya , NOELIA GRANADO MARTINEZ , Miquel Vila

Focus: MDMA

Abstract:

Acute administration of repeated doses of 3, 4‐methylenedioxymethamphetamine (MDMA, ecstasy) dramatically reduces striatal dopamine (DA) content, tyrosine hydroxylase (TH), and DA transporter‐immunoreactivity in mice. In this study, we show for the first time the …