Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3, 4-methylenedioxymethamphetamine,“Ecstasy”) exhibit increased ethanol …

Abstract

MDMA (3, 4-methylenedioxymethamphetamine,“ecstasy”) administration to mice produces relatively selective long-term neurotoxic damage to dopaminergic pathways. There is strong evidence indicating that the dopamine system plays a key role in the rewarding effects of …