MDMA‐induced neurotoxicity: long‐term effects on 5‐HT biosynthesis and the influence of ambient temperature

Abstract

1 3, 4‐Methylenedioxymethamphetamine (MDMA or 'ecstasy') decreases the 5‐HT concentration,[3H]‐paroxetine binding and tryptophan hydroxylase activity in rat forebrain, which has been interpreted as indicating 5‐HT neurodegeneration. This has been …