MDMA (“Ecstasy”) suppresses the innate IFN-γ response in vivo: a critical role for the anti-inflammatory cytokine IL-10

NT Boyle, TJ Connor - European journal of pharmacology, 2007 - Elsevier


Here we demonstrate that the widely abused drug methylenedioxymethamphetamine (MDMA;“Ecstasy”) suppresses innate interferon (IFN)-γ production in mice following an in vivo lipopolysaccharide (LPS) challenge. IFN-γ signalling was also impaired by MDMA, as …

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