MDMA (“Ecstasy”) suppresses the innate IFN-γ response in vivo: a critical role for the anti-inflammatory cytokine IL-10

Abstract

Here we demonstrate that the widely abused drug methylenedioxymethamphetamine (MDMA;“Ecstasy”) suppresses innate interferon (IFN)-γ production in mice following an in vivo lipopolysaccharide (LPS) challenge. IFN-γ signalling was also impaired by MDMA, as …