MDMA (Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion

Abstract

One week after a single administration of 3, 4-methylenedioxymethamphetamine (MDMA· HCl, 30 mg/kg ip), 5-HT 1A receptor density was significantly increased by approximately 25–30% in the frontal cortex and hypothalamus of rats. The increased density correlated with the …