MDMA (ecstasy) effects on cultured serotonergic neurons: evidence for Ca2+-dependent toxicity linked to release

Abstract

Animal studies have established a correlation between release of 5-hydroxytryptamine (5-HT) and the long-term reduction of 5-HT (toxicity) by 3, 4-methylenedioxymethamphetamine (MDMA) with the S (+) enantiomer being more active than the R (-). Using a microculture …