Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum

Abstract

The effects of the MAO-B inhibitors, L-deprenyl and MDL-72974 on MDMA-induced serotonergic neurotoxicity in rats were examined. MDMA alone produced a significant decrease in the number of 5-HT uptake sites, measured as a decrease in the B max for …