Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

Abstract

The aim of this study was to model the in vivo kinetic consequences of mechanism-based inhibition (MBI) of CYP2D6 by 3, 4 methylenedioxymethamphetamine (MDMA, ecstasy). A model with physiologically-based components of drug metabolism was developed, taking …