Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

Abstract

We examined the long term effect of 3, 4 methylenedioxymethamphetamine (MDMA, 10, 20 and 30 mg/kg, ip) on the cerebral 5-hydroxytryptamine (5-HT) and dopamine content in Swiss Webster mice. Three injections of MDMA (20 or 30 mg/kg, ip) given 3 h apart …