Caffeine induces a profound and persistent tachycardia in response to MDMA (“Ecstasy”) administration

Abstract

Caffeine promotes hyperthermia and lethality when co-administered with the recreational drug 3, 4-methylenedioxymethamphetamine (MDMA,“Ecstasy”) to rats. In the present study, co-administration of caffeine (10 mg/kg, sc) with MDMA (10 mg/kg, sc) induced a profound …