Acute toxicity of 3, 4-methylenedioxymethamphetamine (MDMA) in Sprague–Dawley and Dark Agouti rats

A Malpass, JM White, RJ Irvine, AA Somogyi… - Pharmacology …, 1999 - Elsevier

Author(s): Jason White , Andrew Somogyi

Focus: MDMA

Abstract:

Abstract Ingestion of MDMA (“ecstasy”) by humans can cause acute toxicity manifested by hyperthermia and death. Demethylenation of MDMA is catalyzed by cytochrome P-450 2D6 (CYP2D6) and cytochrome P-450 2D1 (CYP2D1) in humans and rats, respectively, and is …