A study of the mechanisms involved in the neurotoxic action of 3, 4‐methylenedioxymethamphetamine (MDMA,'ecstasy') on dopamine neurones in mouse brain

Abstract

Administration of 3, 4‐methylenedioxymethamphetamine (MDMA,'ecstasy') to mice produces acute hyperthermia and long‐term degeneration of striatal dopamine nerve terminals. Attenuation of the hyperthermia decreases the neurodegeneration. We have investigated …