A genetic deletion of the serotonin transporter greatly enhances the reinforcing properties of MDMA in rats

AC Oakly, BW Brox, S Schenk, BA Ellenbroek - Molecular psychiatry, 2014 - nature.com

Author(s): susan schenk , Alana Oakly , Bart Ellenbroek

Focus: MDMA

Abstract:

All drugs of abuse increase synaptic dopamine (DA) but also exert effects on other brain systems that might either enhance or limit subsequent rewarding effects and abuse liability, including serotonin (5-HT). Accordingly, variations in drug-produced DA and/or 5-HT might …