A genetic deletion of the serotonin transporter greatly enhances the reinforcing properties of MDMA in rats

AC Oakly, BW Brox, S Schenk, BA Ellenbroek - Molecular psychiatry, 2014 - nature.com


All drugs of abuse increase synaptic dopamine (DA) but also exert effects on other brain systems that might either enhance or limit subsequent rewarding effects and abuse liability, including serotonin (5-HT). Accordingly, variations in drug-produced DA and/or 5-HT might …

Last updated: Jul 27, 2020