Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion Processing

Brief Summary

The study will test the effect of dopamine, serotonin, and direct 5-HT2A receptor stimulation on empathy, mood perception, and amygdala activity to fearful stimuli. In addition, we predict associations between subjective effects/alterations in emotion processing tests and functional imaging (fMRI) activity.

Intervention / Treatment

  • Drug: LSD
  • Drug: MDMA
  • Drug: Amphetamine
  • Drug: Placebo

Condition or Disease

  • Healthy


Study Design

Study type: Interventional
Status: Completed
Study results: No Results Available
Age: 25 Years to 50 Years   (Adult)
Enrollment: 28 ()
Funded by: Other


Clinical Trial Dates

Start date: Feb 01, 2017
Primary Completion: Aug 11, 2018
Completion Date: Sep 04, 2018
Study First Posted: Jan 13, 2017
Results First Posted: Sep 25, 2020
Last Updated: Oct 15, 2018

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Eligibility Criteria

Sex: All
Minimum Age: 25
Maximum Age: 50

More Details

NCT Number: NCT03019822
Acronym: LAM
Other IDs: BASEC 2016-01827
Study URL:
Last updated: Jun 16, 2022