Effects of MDMA and Methylphenidate on Social Cognition

Brief Summary

The purpose of this study is to assess and compare the effects of a single dose of 3,4-methylenedioxymethamphetamine (MDMA)and methylphenidate (MPH) on emotional and social cognition in healthy subjects. The investigators hypothesize that MDMA enhances affective perception for positive and impairs perception for negative emotional stimuli compared to placebo or MPH.

Intervention / Treatment

  • Drug: 3,4-methylenedioxymethamphetamine
  • Drug: Methylphenidate
  • Drug: Placebo

Condition or Disease

  • Social Cognition


Study Design

Study type: Interventional
Status: Completed
Study results: No Results Available
Age: 18 Years to 45 Years   (Adult)
Enrollment: 30 ()
Funded by: Other


Clinical Trial Dates

Start date: Aug 01, 2012
Primary Completion: Dec 01, 2012
Completion Date: Apr 01, 2013
Study First Posted: Jun 11, 2012
Results First Posted: Aug 30, 2020
Last Updated: Dec 11, 2018

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Eligibility Criteria

Sex: All
Minimum Age: 18
Maximum Age: 45

More Details

NCT Number: NCT01616407
Other IDs: EK 382/11|2012DR1018
Study URL: https://ClinicalTrials.gov/show/NCT01616407
Last updated: Jun 17, 2022