-Methylenedioxymethamphetamine (MDMA, Ecstasy) Induced Changes in Drug Metabolism: Gender and Genetic Polymorphisms

MDMA

Brief Summary

The purpose of this study are:

  1. to evaluate the involvement of CYP2D6, CYP3A4 and CYP1A2 (through dextromethorphan and caffeine challenges), and catechol-O-methyltransferase (COMT)in MDMA metabolism
  2. to evaluate gender differences in the human pharmacology of MDMA
  3. to study the influence of some genetic polymorphisms (CYP2D6, COMT, SERT) in the effects and pharmacokinetics of MDMA.

Intervention / Treatment

  • Drug: MDMA

Condition or Disease

  • Metabolism
  • Interaction

Phase

Study Design

Study type: Interventional
Status: Completed
Study results: No Results Available
Age: 18 Years to 45 Years   (Adult)
Enrollment: 27 ()
Funded by: Other|NIH

Masking

Clinical Trial Dates

Start date: May 01, 2003
Primary Completion: May 01, 2009
Completion Date: May 01, 2011
Study First Posted: Oct 06, 2011
Results First Posted: Aug 30, 2020
Last Updated: Oct 06, 2011

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Location

Barcelona, Spain

Eligibility Criteria

Sex: All
Minimum Age: 18
Maximum Age: 45

More Details

NCT Number: NCT01447472
Other IDs: IMIMFTCL/MDMA/6|AEMPS no.04-0013|5R01DA017987
Study URL: https://ClinicalTrials.gov/show/NCT01447472
Last updated: Jun 17, 2022