When the endogenous hallucinogenic trace amine N, N-dimethyltryptamine meets the sigma-1 receptor

Abstract

N, N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–associated receptor to exert its psychedelic effect. DMT has been recently shown to bind …