The putative anti-addictive drug ibogaine is a competitive inhibitor of MK-801 binding to the NMDA receptor complex

Abstract

Ibogaine is a putative anti-addictive drug with potential efficacy for the treatment of opiate, stimulant, and alcohol abuse. We now report ibogaine is a competitive inhibitor (K i, 1.01±0.1 µM) of [3 H] MK-801 binding to N-methyl-D-aspartate (NMDA) receptor coupled …