The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine

Abstract

Abstract Norharman (20 mg/kg, ip) and ibogaine (40 mg/kg, ip) significantly attenuated naloxone (4 mg/kg, ip)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea …