The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus

Abstract

In the present investigation, Fischer-344 rats were trained to discriminate 10.0 mg kg of ibogaine from water using a pretreatment time of 60 minutes. Analysis of dose response data generated an ED 50 of 4.6 mg kg. The time course of the ibogaine (10.0 mg kg) cue …