Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: relationship to serotonin receptors

Abstract

Abstract d-[3 H] LSD binds saturably, reversibly, and with a high affinity (KD= 10nM) to rat brain membranes. The association and dissociation rates of binding are temperature dependent and fastest at 37° C. Binding is enriched in crude microsomal (P3) membranes. d …