Stereoselective pharmacokinetics of ketamine: R(−)‐Ketamine inhibits the elimination of S(+)‐ketamine

Abstract

Objective We investigated the pharmacokinetics of ketamine with special regard to enantiomer‐specific differences. Methods Ten healthy young male volunteers (mean age, 28±4 years; mean weight, 79±11 kg) received racemic ketamine and S (+)‐ketamine in a …