SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist

Abstract

An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT 2C receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive–compulsive disorder, as …