Prior morphine exposure enhances ibogaine antagonism of morphine-induced dopamine release in rats

Abstract

The present study examines the effect of prior morphine exposure on ibogaine antagonism of morphine-induced dopamine release. Female Sprague-Dawley rats were pretreated once a day for 2 days with morphine (20 mg/kg, ip) or saline and given a low dose of ibogaine (10 …