Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis

Abstract

The effects of the indolehallucinogen psilocybin, a mixed 5-HT 2 and 5-HT 1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15-or 20-mg dose of …