Noribogaine (12‐hydroxyibogamine): a biologically active metabolite of the antiaddictive drug ibogaine

Abstract

Ibogaine (IBO) is a plant‐derived alkaloid that is being evaluated as a possible medication for substance use disorders. When administered peripherally to monkeys and humans, IBO is rapidly converted to an o‐demethylated metabolite, 12‐hydroxyibogamine (NORIBO). We …