Neuropharmacological characterization of local ibogaine effects on dopamine release

Abstract

Summary Local perfusion with ibogaine (10− 6 M—10− 3 M) via microdialysis probes in the nucleus accumbens or striatum of rats produced a biphasic dose-response effect on extracellular dopamine levels. Lower doses (10− 6 M—10− 4 M) produced a decrease while …