Modulation of morphine-induced antinociception by ibogaine and noribogaine

Abstract

The potential modulation of morphine antinociception by the putative anti-addictive agent ibogaine and its active metabolite (noribogaine) was investigated in rats with the radiant heat tail-flick test. Ibogaine pretreatment (40 mg/kg, ip, 19 h) significantly decreased …