Modified Ibogaine Fragments: Synthesis and Preliminary Pharmacological Characterization of 3-Ethyl-5-phenyl-1,2,3,4,5,6-hexahydroazepino …

Abstract

Five phenyl-substituted derivatives and analogues of 1, 2, 3, 4, 5, 6-hexahydroazepino [4, 5-b] indole, 5, a major fragment of ibogaine (1), were synthesized and tested for binding to monoamine transporters, the NMDA receptor-coupled cation channel, and dopamine and …