Mechanisms of action of ibogaine: relevance to putative therapeutic effects and development of a safer iboga alkaloid congener

Abstract

Publisher Summary Ibogaine, an alkaloid extracted from Tabernanthe iboga (Apocynaceae), is being used in uncontrolled clinical trials as a long-acting treatment for opioid and stimulant abuse, alcoholism, and smoking. In this study, animal models have been used to …