Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies

Abstract

Assays using radioligands were used to assess the actions of ibogaine and harmaline on various receptor types. Ibogaine congeners showed affinity for opiate receptors whereas harmaline and harmine did not. The K i for coronaridine was 2.0 μM at μ-opiate receptors …