Lack of dopamine D 1 receptors in the antidepressant actions of (R)-ketamine in a chronic social defeat stress model

Abstract

… d-aspartate receptor (NMDAR) antagonist (R,S)-ketamine exhibits rapid and sustained antidepressant effects in treatment-resistant patients with major depressive disorder [1,2,3]. (R,S)-ketamine is a racemic mixture containing equal parts of (R)-ketamine (or arketamine) and …