Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin

Abstract

An improved procedure to accomplish the O-phosphorylation of 4-hydroxy-N, N-dimethyltryptamine (psilocin 5) is reported that utilizes reaction between the O-lithium salt of 5 and tetra-O-benzylpyrophosphate. The O-benzyl groups were removed by catalytic …