Ibogaine produces neurodegeneration in rat, but not mouse, cerebellum: Neurohistological biomarkers of Purkinje cell loss

Abstract

The compound Ibogaine is being intensively studied as a possible therapeutic aid to interrupt addictive cravings of various sorts (eg, Ref. 1). Structurally, ibogaine closely resembles serotonin (FIG. 1). It binds, but with only moderate (micromolar) affinity, to a …