Ibogaine labeling with 99mTc-tricarbonyl: synthesis and transport at the mouse blood–brain barrier

Abstract

The 99m Tc-tricarbonyl core may be used as an ideal tool for gamma-labeling ligands in noninvasive SPECT imaging. However, most 99m Tc-tricarbonyl-labeled agents have difficulty crossing the blood–brain barrier (BBB). We radiolabeled the neuroactive indole …