Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat

Abstract

Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg− 1, sc) was administered 15min before naloxone (0.5 mg kg− 1, sc) in morphine dependent rats …