Ibogaine and its congeners are σ2 receptor-selective ligands with moderate affinity

Abstract

Abstract Ibogaine (12-methoxyibogamine) exhibited moderate affinity for σ 2 sites (K i= 201 nM) and low affinity for σ 1 sites (K i= 8554 nM), thus showing 43-fold selectivity for σ 2 receptors. Tabernanthine (13-methoxyibogamine) and (±)-ibogamine had σ 2 K i= 194 nM …