Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo oct-7-enes

Abstract

Two of the most obvious identifiable fragments, that constitute the skeleton of ibogaine, are 2-ethylindolyl and isoquinuclidinyl ones. Previously, tropane-3-indoles 7a and hexahydroazepinobenzothiophenes 7b have been synthesized as abbreviated ibogaine analogues and they have been found to …