Ibogaine: a potent noncompetitive blocker of ganglionic/neuronal nicotinic receptors
B Badio, WL Padgett, JW Daly - Molecular pharmacology, 1997 - ASPET
Abstract
Ibogaine noncompetitively blocked (IC 50∼ 20 nm) 22 NaCl influx through ganglionic-type nicotinic receptor channels of rat pheochromocytoma PC12 cells. The major metabolite O-desmethylibogaine was 75-fold less active, andO-t-butyl-O-desmethylibogaine was 20-fold …
Last updated: Jul 27, 2020