Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter

Abstract

Ibogaine, a hallucinogenic alkaloid with purported anti-addiction properties, inhibited serotonin transporter (SERT) noncompetitively by decreasing V max with little change in the Km for serotonin (5-HT). Ibogaine also inhibited binding to SERT of the cocaine analog 2β-2 …