Evidence for roles of κ-opioid and NMDA receptors in the mechanism of action of ibogaine

SD Glick, IM Maisonneuve, SM Pearl - Brain research, 1997 - Elsevier

Abstract

Ibogaine, a putatively anti-addictive alkaloid, binds to κ-opioid and NMDA receptors. In the present study we investigated the roles of κ-opioid and NMDA actions in mediating ibogaine's (40 mg/kg, ip) behavioral and neurochemical effects in rats. A combination of a k …

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