Effects of ibogaine on the development of tolerance to antinociceptive action of μ-, δ-and κ-opioid receptor agonists in mice

Abstract

The effects of ibogaine, an alkaloid isolated from the bark of the African shrub, Tabernanthe iboga, on the development of tolerance to the antinociception action of morphine, U-50,488 H and [d-Pen 2, d-Pen 5] enkephalin (DPDPE), which are μ-, κ-and δ-opioid receptor …