Effects of a ketamine metabolite on synaptic NMDAR function

Abstract

Clinical data have demonstrated rapid and sustained antidepressant effects of ketamine, a noncompetitive NMDAR (N-methyl-daspartate receptor) antagonist 1. Recently, Zanos et al. 2 claimed that the ketamine metabolite (2R, 6R)-hydroxynorketamine (HNK) is essential for …