Effect of ibogaine on the development of tolerance to the analgesic effect of morphine.

Abstract

The results of 3 experiments demonstrated that (a) 20 mg/kg ibogaine (but not 10 mg/kg), administered 30 min before morphine, attenuates the development of tolerance to the analgesic effect of morphine in rats;(b) this 20 mg/kg dose of ibogaine, if administered 5 hr …