An improved, practical, and scalable five-step synthesis of psilocybin

Abstract

Described herein is an improved synthesis of 3-[2-(dimethylamino) ethyl]-1H-indol-4-yl dihydrogen phosphate (psilocybin). The protocol outlines: synthesis of multigram quantities of psilocybin, identification of critical in-process parameters, and isolation of psilocybin …