18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of antiaddictive efficacy, toxicity, and mechanisms of action

Abstract

18-MC, a novel iboga alkaloid congener, is being developed as a potential treatment for multiple forms of drug abuse. Like ibogaine (40 mg/kg), 18-MC (40 mg/kg) decreases the intravenous self-administration of morphine and cocaine and the oral self-administration of …